Both the presence of urothelial dysfunction and abnormalities of sensory receptor expression or transmitter release in the suburothelial nerves may contribute to OAB, which is refractory to antimuscarinics 3. Antimuscarinic agents are the first-line treatment, with a success rate greater than 70% 2. Overactive bladder syndrome (OAB) is characterized by urgency with or without urge incontinence and is usually associated with frequency and nocturia 1. Besides, logit(p) <0.34 can be used to predict large PVR for its higher ROC area. In conclusion, low 3-day daytime frequency episodes (<25) and low voiding efficiency (<89%) are associated with large PVR. The median value of the persistent large PVR interval was 5 months. The predicted logit transformation of probability of large PVR, logit(p), for a given 3-day daytime frequency episodes ( a) and voiding efficiency ( b%) can be denoted by logit(p) = −5.18 + 0.07 × a + 0.04 × b, with a cutoff value of logit(p) = 0.34 and a ROC area of 0.79. A receiver operating characteristic (ROC) curve analysis showed the following optimum cut-off values: (1) 3-day daytime frequency episodes = 25, which has a ROC area of 0.72 and (2) voiding efficiency = 89%, which has a ROC area being 0.66. Multivariate analysis found that the baseline 3-day daytime frequency episodes and voiding efficiency were independent predictors for postoperative large PVR. The data showed that 133 of 290 patients had a large PVR after treatment. The aim of this study was to identify factors predicting large post-void residual (PVR) (defined as ≥200 mL), an important unsolved problem, after an intravesical injection of onabotulinumtoxinA in patients with overactive bladder syndrome.
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